In September 2016 we searched the Cochrane Wounds Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations), Ovid Embase, and EBSCO CINAHL. To assess the effects and safety of antiseptics for the treatment of burns in any care setting. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. Antiseptics are topical agents that act to prevent growth of micro-organisms. People with burns are particularly vulnerable to infections over 75% of all burn deaths (after initial resuscitation) result from infection. Norman, Gill Christie, Janice Liu, Zhenmi Westby, Maggie J Jefferies, Jayne M Hudson, Thomas Edwards, Jacky Mohapatra, Devi Prasad Hassan, Ibrahim A Dumville, Jo Cīurn wounds cause high levels of morbidity and mortality worldwide. © 2015 British Association of Dermatologists. Aqueous eosin and potassium permanganate may have desirable astringent properties, but these results suggest they lack effective antiseptic activity, at least against S. aureus count, neither 2% aqueous eosin nor 1 : 10 000 potassium permanganate showed significant bactericidal activity compared with control at exposure periods of up to 1 h. While 1% benzalkonium chloride and 6% hydrogen peroxide both achieved a 5 log10 reduction in S. To meet the standard for antiseptic effectiveness of EN 1276, at least a 5 log10 reduction in bacterial count within 5 minutes of exposure is required. We tested the in vitro bactericidal activity of four commonly used topical antiseptics against Staphylococcus aureus, using a modified version of the European Standard EN 1276, a quantitative suspension test for evaluation of the bactericidal activity of chemical disinfectants and antiseptics. Topical antiseptics are frequently used in dermatological management, yet evidence for the efficacy of traditional generic formulations is often largely anecdotal.
Quantitative evaluation of dermatological antiseptics.
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